5α-reductase activity in cultured dermal papilla cells
نویسندگان
چکیده
منابع مشابه
Whisker growth induced by implantation of cultured vibrissa dermal papilla cells in the adult rat.
Retention of the capacity to induce the growth of hair by cultured adult rat vibrissa dermal papilla cells has been investigated. Small pellets of serially cultured papilla cells were implanted into the bases of the exposed follicular epidermis of amputated adult rat vibrissa follicles. Amputated follicles that received no cell implants or implants of cultured dorsal skin fibroblasts were used ...
متن کاملEpigallocatechin Gallate-Mediated Alteration of the MicroRNA Expression Profile in 5α-Dihydrotestosterone-Treated Human Dermal Papilla Cells
BACKGROUND Dihydrotestosterone (DHT) induces androgenic alopecia by shortening the hair follicle growth phase, resulting in hair loss. We previously demonstrated how changes in the microRNA (miRNA) expression profile influenced DHT-mediated cell death, cell cycle arrest, cell viability, the generation of reactive oxygen species (ROS), and senescence. Protective effects against DHT have not, how...
متن کاملCultured dermal papilla cells induce follicle formation and hair growth by transdifferentiation of an adult epidermis.
Adult rat pelage follicle dermal papilla cells induced follicle neogenesis and external hair growth when associated with adult footpad skin epidermis. They thus demonstrated a capacity to completely change the structural arrangement and gene expression of adult epidermis--an ability previously undocumented for cultured adult cells. Isolation chambers ensured that de novo follicle formation must...
متن کاملEvaluation of animal models for the hair-inducing capacity of cultured human dermal papilla cells.
BACKGROUND The dermal papilla (DP) interacts with epithelial cells for folliculogenesis. For translational research on cell therapies for hair regrowth with cultured human DP cells (hDPCs), a model to evaluate the capacity of hDPCs to induce hair formation is inevitable. METHODS Chamber models were constructed by transplanting 4 different combinations of mouse or human epithelial and mesenchy...
متن کاملCiprofloxacin Improves the Stemness of Human Dermal Papilla Cells
Improvement in the expansion method of adult stem cells may augment their use in regenerative therapy. Using human dermal papilla cell line as well as primary dermal papilla cells as model systems, the present study demonstrated that ciprofloxacin treatment could prevent the loss of stemness during culture. Clonogenicity and stem cell markers of dermal papilla cells were shown to gradually decr...
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ژورنال
عنوان ژورنال: Juntendo Medical Journal
سال: 1992
ISSN: 0022-6769,2188-2134
DOI: 10.14789/pjmj.37.566